Table 1 Main association results for variant-trait significant findings.
Trait | Chr:position (hg19) | Gene | Marker exonic function | Amino acid change | Coded/Other allele | Minor Allele Count | N | Effect | Variance explained (%) | p-value | Functional prediction of SNV* |
---|---|---|---|---|---|---|---|---|---|---|---|
Serum creatinine | 1:101,342,412 | EXTL2 | Missense | p.M148V | G/A | 33 | 1125 | − 0.527 | 2.42 | 8.7 × 10–9 | Deleterious |
Serum creatinine | 17:35,518,712 | ACACA | Missense | p.P1683S | A/G | 26 | 1125 | − 0.506 | 1.87 | 2.9 × 10–7 | Deleterious |
Fasting triglycerides | 17:67,149,477 | ABCA10 | rs779392624 missense | p.G1369W | A/C | 17 | 1124 | − 0.696 | 2.15 | 7.5 × 10–9 | Deleterious |
Fasting insulin | 6:79,650,711 | PHIP | Missense | p.T1722I | A/G | 28 | 790 | − 0.369 | 1.30 | 2.1 × 10–6 | Deleterious |
Fasting insulin | 9:73,152,248 | TRPM3 | rs760461668 missense | p.V1086M | A/G | 185 | 792 | 0.166 | 1.70 | 4.8 × 10–8 | Deleterious |
Fasting insulin | 11:18,637,366 | SPTY2D1 | rs756851199 missense | p.V152A | G/A | 109 | 793 | 0.220 | 1.75 | 1.6 × 10–8 | Neutral/tolerant |
Fasting insulin | 22:43,557,062 | TSPO | rs566547284 missense | p.G63S | A/G | 26 | 793 | 0.396 | 1.45 | 2.4 × 10–6 | Deleterious |