Figure 1 | Scientific Reports

Figure 1

From: Different DNA methylome, transcriptome and histological features in uterine fibroids with and without MED12 mutations

Figure 1

DNA methylation profiling of the MED12m-positive and -negative uterine fibroids, and myometrium. (a) DNA methylation profiles of the MED12m-positive and -negative uterine fibroids, and myometrium were compared using hierarchical clustering analyses. Distances of DNA methylation pattern are indicated as height. Each color indicates the myometrium (light blue), the MED12m-positive uterine fibroids (red), and the MED12m-negative uterine fibroids (green). The MED12m-negative uterine fibroids were further classified into three different clusters, Subtype-1, Subtye-2, and Subtype-3. (b) Chromosomal distribution of hyper- or hypomethylated CpGs in the MED12m-positive and -negative uterine fibroids (Subtype-1, -2, and -3) compared to the myometrium are shown. The locations of CpG sites, which have p < 0.05 and beta-value difference > 0.2 compared to the myometrium, are indicated with red (hypermethylated CpGs) or blue (hypomethylated CpGs). Autosomal and sex chromosome numbers are shown on the top.

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