Table 6 Time-to-event analyses for baseline factor levels and death or heart failure hospitalization.

From: Plasma metabolites associated with functional and clinical outcomes in heart failure with reduced ejection fraction with and without type 2 diabetes

Factor

Overall

Diabetic

Non-diabetic

HR (95% CI)

P-value

Prop. Haz. P-val

HR (95% CI)

P-value

Prop. Haz. P-val

HR (95% CI)

P-value

Prop. Haz. P-val

Basic

1

1.13 (0.89–1.44)

0.300

0.436

0.94 (0.66–1.32)

0.707

0.691

1.75 (1.17–2.61)

0.006

0.659

2

0.88 (0.72–1.08)

0.222

0.859

0.95 (0.73–1.23)

0.683

0.321

0.83 (0.60–1.14)

0.252

0.751

4

1.51 (1.21–1.90)

3 × 10–4

0.506

1.58 (1.20–2.07)

0.001

0.414

1.44 (0.93–2.24)

0.106

0.697

5

1.15 (0.97–1.37)

0.106

0.056

1.06 (0.81–1.40)

0.678

0.031

1.26 (0.99–1.60)

0.065

0.381

7

1.03 (0.85–1.24)

0.801

0.673

1.10 (0.84–1.44)

0.510

0.360

0.92 (0.68–1.22)

0.551

0.847

8

0.92 (0.75–1.13)

0.437

0.550

0.92 (0.71–1.19)

0.514

0.538

0.96 (0.69–1.35)

0.829

0.923

11

0.90 (0.75–1.09)

0.292

0.642

0.88 (0.68–1.15)

0.355

0.334

0.91 (0.69–1.22)

0.534

0.604

13

1.24 (0.98–1.58)

0.077

0.841

0.98 (0.70–1.37)

0.891

0.386

1.70 (1.15–2.49)

0.007

0.338

Fulla

4

1.50 (1.12–2.00)

0.007

0.524

1.58 (1.12–2.21)

0.009

0.351

1.07 (0.61–1.87)

0.825

0.493

  1. Significant values are in bold.
  2. aFull model: time to heart failure hospitalization or death ~ baseline factor + age + sex + race + randomization drug + BMI + baseline creatinine + SBP + baseline NT-proBNP + liver function tests.
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