Table 1 Cytotoxicity of erlotinib, afatinib or osimertinib in H1975 and osimertinib-resistant cell lines.

From: AXL/CDCP1/SRC axis confers acquired resistance to osimertinib in lung cancer

Cell lines

EGFR mutations

Selected drug

IC50 (µmol/L)a

Erlotinib

Afatinib

Osimertinib

H1975

L858R + T790M

 

5.48 (1.00)

0.21 (1.00)

0.014 (1.00)

H1975/OR1

 

Osimertinib

6.30 (1.15)

0.94 (4.48)

4.0 (286)

H1975/OR2

 

Osimertinib

6.97 (1.27)

0.66 (3.14)

4.04 (289)

  1. aThe relative resistance, defined as the IC50 value divided by the IC50 value of the parental cells, is shown in parentheses.
Back to article page