Figure 4 | Scientific Reports

Figure 4

From: LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis

Figure 4

Gene ontology pathways in human, pig, and mouse LGR5-expressing epidermal populations are enriched in extracellular matrix structure and organization. (A) Top significantly upregulated (25) and downregulated (25) genes between LGR5-H2BGFP-high and LGR5-H2BGFP negative sorted pig samples. Bulk RNAseq samples were prepared from sorted populations from two pigs. Note confirmation of LGR5 and SOX9 upregulation in the LGR5-H2BGFP high population. (B) Comparison of all three species showing common gene ontology terms from genes that are upregulated in LGR5-high epidermis across all three species. (C) Upstream regulators that target a significant portion of the genes that are upregulated in LGR5 + cells from mice, human, and pig datasets. Each bar represents significance (negative log) of a set of multiple genes that impact a single regulatory pathway.

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