Figure 5

Sequencing analysis in FGFR4-G388R variant and immunostaining of phosphorylated STAT3. Phospho-serine (p-S)727 STAT3 was strongly positive in the nucleus of the adrenocortical adenoma component of Case 3, and weakly positive in Case 1. Phospho-tyrosine (p-Y)705 STAT3 was not detected in any case.