Figure 5 | Scientific Reports

Figure 5

From: Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling

Figure 5

(a) Endothelium-dependent and (b) -independent vasodilation and (c) ADMA plasma levels in DDAH1 KO/AGXT2 WT, DDAH1 KO/AGXT2 WT, DDAH1 WT/AGXT2 TG and DDAH1 KO/AGXT2 TG mice. Ach acetylcholine, SNP sodium nitroprusside. Two-way repeated-measures ANOVA followed by Sidak multiple comparison test (a,b), *p < 0.05; **p < 0.01; p < 0.001 DDAH1 KO/AGXT2 WT vs. DDAH1 KO/AGXT2 TG. One-way ANOVA followed by Tukey’s multiple comparison test (c), ***p < 0.001; ****p < 0.0001. N = 8–15 (a,b), 4–9 (c). Cohen’s d = (c) 4.6 (DDAH1 WT/AGXT2 WT vs DDAH1 KO/AGXT2 WT) and 2.5 (DDAH1 KO/AGXT2 WT vs DDAH1 KO/AGXT2 TG).

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