Table 1 Baseline sample characteristics, stratified by categories of FXI:C (%).
FXI:C (%) | |||
|---|---|---|---|
Low (< 70%) (n = 43) | Normal (70–150%) (n = 412) | High (> 150%) (n = 94) | |
Female sex, % (n) | 41.9 (18) | 40.5 (167) | 56.4 (53) |
Age (years) | 55.3 ± 16.9 | 60.7 ± 16.6 | 57.8 ± 15.5 |
Body mass index (kg/m2) | 26.1 (23.4/30.9) | 28.2 (24.7/31.8) | 29.2 (25.2/33.2) |
Deep vein thrombosis (DVT), % (n) | 80.5 (33) | 81.3 (308) | 83.3 (75) |
Pulmonary embolism (PE), % (n) | 62.8 (27) | 75.7 (312) | 64.9 (61) |
VTE risk factors | |||
History of DVT, % (n) | 27.5 (11) | 26.8 (104) | 30.1 (28) |
History of PE, % (n) | 8.3 (3) | 11.1 (44) | 11.8 (11) |
Recent immobilization, % (n) | 12.2 (5) | 15.8 (63) | 9.7 (9) |
Recent surgery, n (%) | 4.8 (2) | 6.2 (25) | 2.2 (2) |
Recent trauma, n (%) | 7.3 (3) | 3.8 (15) | 5.4 (5) |
Thrombophilia, n (%) | 8.3 (3) | 4.6 (15) | 3.5 (3) |
Cardiovascular risk factors | |||
Active smoking, % (n) | 26.8 (11) | 16.1 (61) | 20.2 (19) |
Arterial hypertension, % (n) | 48.8 (20) | 52.2 (204) | 48.9 (45) |
Diabetes mellitus, % (n) | 15.0 (6) | 12.0 (47) | 15.1 (14) |
Comorbidities | |||
Atrial fibrillation, % (n) | 0 (0) | 5.1 (20) | 3.3 (3) |
Congestive heart failure, % (n) | 10.3 (4) | 4.2 (16) | 5.5 (5) |
Coronary artery disease, % (n) | 12.8 (5) | 7.5 (29) | 3.3 (3) |
History of stroke, % (n) | 2.5 (1) | 4.6 (18) | 5.5 (5) |
Chronic kidney disease, % (n) | 10.0 (4) | 5.2 (20) | 7.5 (7) |
Chronic liver disease, % (n) | 11.6 (5) | 4.9 (19) | 2.2 (2) |
Chronic pulmonary disease, % (n) | 16.7 (7) | 11.5 (46) | 12.9 (12) |
Medication | |||
Vitamin K antagonists, % (n) | 4.7 (2) | 5.6% (23) | 8.5% (8) |
Heparin group, % (n) | 44.2 (19) | 58.7 (242) | 57.4 (54) |
Platelet aggregation inhibitors, % (n) | 23.3 (10) | 30.1 (124) | 17.0 (16) |
Direct Thrombin inhibitors, % (n) | 4.7 (2) | 1.2 (5) | 0 (0) |
Direct FXa inhibitors, % (n) | 32.6 (14) | 27.4 (113) | 20.2 (19) |
Cardiovascular medication, % (n) | 53.5 (23) | 63.3 (261) | 47.9 (45) |
Contraceptives, % (n) | 7.0 (3) | 1.9 (8) | 7.4 (7) |
Anti-inflammatory, % (n) | 7.0 (3) | 5.1 (21) | 4.3 (4) |
Laboratory markers | |||
C-reactive protein (mg/l) | 9.26 (2.52/33.97) | 15.77 (5.1/44.1) | 22.28 (7.29/60.3) |
Platelets (/nl) | 223.0 (162.0/326.7) | 224 (185.7/273) | 262 (221.2/300) |
APTT (s) | 36.40 (31.7/44.2) | 33.50 (30.5/37.5) | 30.60 (27.9/32.8) |
Prothrombin activity (%) | 75.51 ± 27.00 | 82.56 ± 21.16 | 90.44 ± 19.87 |
