Figure 1 | Scientific Reports

Figure 1

From: HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function

Figure 1

Genetic characteristics of a case of colorectal cancer harboring HER2 G776S mutation detected by clinical NGS. (A) Summary of the patient's clinical profile. (B) Comprehensive genomic analysis report of the cancer of the patient. Positive biomarkers are shown. (C) Sanger sequencing of a part of HER2 gene of the cancer genome DNA. The amino acid (a.a.) sequence from 774 to 778 is shown. The sequence of the corresponding wild-type (WT) site is also presented. The red arrow indicates the mutation position of G776S. (D) The mutation position of G776 in HER2 protein domains based on the COSMIC database. The nucleotide sequences of the WT, G776S and G776 > VC are described. The underlined part indicates a substitution mutation and the yellow background site indicates a short insertion. Recep_L, receptor L domain; Furin-like, furin-like cysteine-rich region; GF_recep_IV, growth factor receptor domain IV. In the lower part of the figure, the number of reports in the COSMIC database and annotations from OnkoKB (https://www.oncokb.org/) are shown. The data are current as of April 2021.

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