Table 6 Patient characteristics between accelerated-strategy group and standard-strategy group (at baseline and at the start of CRRT).

From: Clinical outcomes of severe sepsis and septic shock patients with left ventricular dysfunction undergoing continuous renal replacement therapy

Characteristics

Accelerated strategy (n = 40)

Standard strategy (n = 34)

p

Age, years

61.48 ± 9.14

63.88 ± 8.50

0.248

Male, n (%)

27 (67.50)

23 (67.65)

0.989

BMI, kg/m2

24.74 ± 3.12

24.78 ± 3.33

0.965

MAP, mmHg

83.53 ± 5.06

82.91 ± 5.69

0.625

Laboratory tests

Leukocyte count, × 109/L

15.75 ± 3.28

14.9 ± 3.47

0.286

Neutrophil percentage, %

81.05 ± 6.11

80.80 ± 8.40

0.888

PLT count, × 109/L

175.92 ± 57.34

179.82 ± 50.88

0.760

Blood pH

7.33 ± 0.06

7.35 ± 0.06

0.060

Baseline creatinine, mg/dL

0.89 ± 0.28

1.00 ± 0.31

0.102

Serum potassium, mEq/L

4.89 ± 0.69

4.79 ± 0.68

0.538

Baseline eGFR, mL/min/1.73 m2

84.32 ± 20.14

75.02 ± 23.40

0.070

BUN, mg/dL

16.20 ± 2.77

15.57 ± 3.51

0.407

CK-MB, IU/L

20.15 ± 16.15

22.26 ± 13.21

0.544

ALT, U/L

59.63 ± 57.42

45.29 ± 42.96

0.235

Total bilirubin, mg/dL

1.31 ± 1.17

1.08 ± 0.71

0.319

Lactate, mg/dL

58.44 ± 27.89

59 ± 37.78

0.941

Hb, g/L

131.78 ± 14.46

130.50 ± 10.60

0.671

Six-hour UO at admission, mL

461.53 ± 150.72

459.29 ± 126.9

0.946

Primary diagnosis

Pneumo-sepsis, n (%)

9 (22.50)

14 (41.18)

0.084

Urosepsis, n (%)

1 (2.50)

4 (11.76)

0.173

Abdominal sepsis, n (%)

18 (45.00)

10 (29.41)

0.168

Other cause, n (%)

12 (30.00)

6 (17.65)

0.217

Type of surgery

Abdominal surgery, n (%)

2 (5.00)

1 (2.94)

> 0.999

Urinary surgery, n (%)

0 (0)

0 (0)

–

Others, n (%)

0 (0)

1 (2.94)

0.459

Postoperative, n (%)

2 (5.00)

2 (5.88)

> 0.999

Positive blood culture, n (%)

13 (32.50)

17 (50.00)

0.127

Invasive MV, n (%)

23 (57.50)

24 (70.59)

0.244

Comorbidities

Hypertension, n (%)

7 (17.50)

12 (35.29)

0.081

Diabetes mellitus, n (%)

6 (15.00)

6 (17.65)

0.758

Coronary artery disease, n (%)

3 (7.50)

2 (5.88)

> 0.999

Heart failure, n (%)

2 (5.00)

7 (20.59)

0.071

Medication at admission

Noradrenaline, n (%)

27 (67.50)

22 (64.71)

0.800

Dopamine, n (%)

6 (15.00)

6 (17.65)

0.758

Glucocorticoid, n (%)

7 (17.50)

6 (17.65)

0.987

Digitalis during hospitalization, n (%)

6 (15.00)

5 (14.71)

0.972

Resuscitation fluid in first 36 h (crystal solution), mL

3066.25 ± 520.90

3063.24 ± 333.33

0.976

Echocardiography

LVEDD, mm

48.82 ± 3.01

48.49 ± 2.77

0.629

LVESD, mm

35.18 ± 3.53

35.14 ± 3.55

0.965

CO, L/min

3.93 ± 0.88

4.05 ± 0.72

0.522

LVEF, %

51.06 ± 14.33

51.95 ± 12.13

0.774

E, m/s

0.80 ± 0.23

0.83 ± 0.21

0.665

A, m/s

0.83 ± 0.19

0.76 ± 0.16

0.138

E/A

0.99 ± 0.27

1.11 ± 0.34

0.115

e′, m/s

0.07 ± 0.03

0.07 ± 0.03

0.879

E/e′

13.11 ± 6.12

13.44 ± 5.63

0.814

Cardiac function

0.778

Systolic dysfunction, n (%)

11 (27.50)

7 (20.59)

 

Diastolic dysfunction, n (%)

22 (55.00)

20 (58.82)

 

Systolic and diastolic dysfunction, n (%)

7 (17.50)

7 (20.59)

 

SOFA scores

12.65 ± 2.07

12.12 ± 1.79

0.245

APACHE II scores

25.38 ± 3.36

23.97 ± 2.98

0.063

CRRT protocol mode

0.016

CVVH

19 (47.50)

7 (20.59)

 

CVVHDF

21 (52.50)

27 (79.41)

 

Anticoagulant

0.098

Sodium citrate

23 (57.50)

13 (38.24)

 

Heparin

17 (42.50)

21 (61.76)

 

Blood flow, mL/min

154.25 ± 18.69

147.5 ± 16.01

0.103

CRRT dose, mL/kg/h

29.35 ± 3.43

29.53 ± 3.55

0.826

Ultrafiltration dose, mL/kg/h

27.33 ± 2.03

27.09 ± 1.94

0.612

Dialysis dose, mL/kg/h

20.48 ± 4

19.63 ± 3.25

0.422

At the start of CRRT

Noradrenaline, n (%)

21 (100)

23 (100)

–

Noradrenaline, μg/kg/min

0.24 ± 0.23

0.2 ± 0.19

0.524

Six-hour UO before CRRT initiation, mL

142.55 ± 65.46

161.47 ± 53.78

0.183

Total duration CRRT, hour

84.35 ± 21.93

85.94 ± 14.54

0.711

Creatinine, mg/dL

2.59 ± 1.06

2.55 ± 0.91

0.871

MAP, mmHg

90.35 ± 10.47

89.12 ± 11.25

0.627

SOFA

14.38 ± 2.24

13.76 ± 2.12

0.235

APACHE II

30.35 ± 4.62

28.62 ± 4.61

0.112

At the end of CRRT

Noradrenaline, n (%)

21 (52.50)

16 (47.06)

0.641

Noradrenaline, μg/kg/min

0.23 ± 0.12

0.20 ± 0.11

0.512

Creatinine, mg/dL

1.92 ± 1.01

1.72 ± 0.82

0.365

MAP, mmHg

96.78 ± 17.59

92.76 ± 12.17

0.253

SOFA

9.83 ± 5.93

9.88 ± 5.85

0.967

APACHE II

19.73 ± 9.63

18.94 ± 8.89

0.719

CRRT start time, hours

7.16 ± 2.91

39.03 ± 19.26

< 0.001

  1. BMI body mass index, MAP mean arterial pressure, PLT platelet, eGFR estimated glomerular filtration rate, BUN blood urea nitrogen, CK-MB creatine kinase-MB, ALT alanine aminotransferase, MV mechanical ventilation, LV left ventricle, LVEDD LV end diastolic dimension, LVESD LV end systolic dimension, CO cardiac output, LVEF LV ejection fraction, SOFA Sequential Organ Failure Assessment, APACHE II Acute Physiologic Assessment and Chronic Health Evaluation II, CRRT continuous renal replacement therapy, UO urine output, OR odds ratio, CI confidence interval.
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