Figure 4
Global gene expression profile of MT-F7 and MC-F7 cells based on RNA-seq analysis. (a) The overall alignment rate of MT-F7 cells was greater than that of MC-F7 cells (96% vs. 85%). (b) Pearson correlation analysis showed similar global transcriptional profiles among samples of MC-F7 and MT-F7 cells. (c) Heatmap shows the fold changes of 1962 DEGs (|log2FC |> 1.5; P value < 0.05) in MT-F7 cells compared to the MC-F7 cells. The gene read counts were consistent between the MT-F7 and MC-F7 samples. (d) The volcano map shows significantly higher expression of 1020 genes and reduced expression of 942 genes in the MT-F7 cells compared to the MC-F7 cells. (e–h) The top 10 GO terms and KEGG pathways (up and down) based on the differentially expressed genes (DEGs) between MC-F7 and MT-F7 cells. The enriched GO terms or KEGG pathways with the most gene counts and Gene Ratio were analyzed at the genetic level (above the red lines).
