Figure 2
From: Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody
(a) Projections of protein \({C}_{\alpha }\) positions along principal components 1 and 2 shows that the essential dynamics of the protein is entirely governed by Fab1 dynamics. Contributions from Fab2 and Fc along the first two principal directions are negligible. (b) Snapshots of 1HZH showing the contributions of each \({C}_{\alpha }\) atom to principal component 1 (top) and principal component 2 (bottom). The size of the arrows is directly proportional to the contributions and the backbone alpha carbons are displayed as spheres.
