Table 1 Characteristics of 60 RA patients at baseline.

From: Predictors of long-term prognosis in rheumatoid arthritis-related interstitial lung disease

 

RA-no ILD

RA-indeterminate ILD

RA-mild ILD

RA-advanced ILD

(ILA score 0)

(ILA score 1)

(ILA score 2)

(ILA score 3)

(n = 22)

(n = 24)

(n = 12)§

(n = 2)Ŧ

Demographic parameters

Age, years, mean ± SD

38.9 ± 16

51.4 ± 14.8*

62.2 ± 7.7***

75.5 ± 0.7*

Female, no. (%)

18 (82)

21 (88)

9 (75)

0 (0)

Smoker, no. (%)

    

Never

19 (86)

22 (92)

11 (92)

0 (0)

Ever

3 (14)

2 (8)

1 (8)

2 (100)

Current

1 (5)

0 (0)

1 (8)

0 (0)

Pack-years of smoking, mean ± SD

1.1 ± 5.3

1.7 ± 5.6

2.5 ± 8.7

10.0 ± 14.1

Pack-years of secondhand smoking, mean ± SD

0 ± 0

1.0 ± 3.6

0.9 ± 2.9

10.0 ± 14.1

RA parameters, median (IQR)

RF, IU/ml

47.5 (27.8–147.0)

191.5 (79.9–357.5)

324.5 (91.8–666.5)

905.5(538.2–1272.8)

Anti-CCP, units/ml

86.9 (54.3–290.4)

291.5 (62.1- 414.6)

480.1 (253–500.0)

351.7 (277.6–425.9)

DAS28

4.0 (2.4–5.1)

4.2 (3.4–5.2)

4.4 (3.7–5.2)

3.5 (3.2–3.9)

Duration of RA, years

3.5 (1.2–7.5)

2.0 (0.7–10)

5.5 (1.4–10)

2.0 (1.5–2.5)

Medication use (ever) at baseline, no. (%)

Methotrexate

22 (100)

24 (100)

12 (100)

2 (100)

Leflunomide

10 (45)

9 (38)

4 (33)

0 (0)

Corticosteroid

2 (9)

5 (21)

2 (17)

1 (50)

Biologic

2 (9)

1 (4)

0 (0)

0 (0)

Respiratory parameters, no. (%)

Cough

0 (0)

1 (4)

2 (17)

1 (50)

Dyspnea

0 (0)

1 (4)

2 (17)

1 (50)

Spirometric parameters, median (IQR)

FEV1, percent of predicted

83.0 (76.5–95.5)

86.0 (76.5–90.0)

79.0 (65.0–87.2)

79.5 (66.8–92.2)

FVC, percent of predicted

79.0 (75.5–93.5)

83.0 (76.0–89.0)

73.0 (67.5–78.5)

86 (71.5–100.5)

Dlco, percent of predicted

86.0 (76.5–104.0)

94.0 (68.0–101)

60.0 (52.5–69.5)**

59 (56.5–61.5)

Quantitative Modified ILD scoring in HRCT, median (IQR)

 

0.8 (0.0–1.0)

2.0 (1.4–4.0) ***

8.0 (4.2–12.1)***

12.5 (12.2–12.8)*

  1. RF = rheumatoid factor; anti-CCP = anti–cyclic citrullinated peptide; DAS28 = 28-joint Disease Activity Score. IQR = interquartile range. Age was significantly different among the subgroups: RA-mild ILD (ILA score2) and RA-no ILD (ILA score 0) (p < 0.001), RA–advanced ILD (ILA score3) and RA-no-ILD (ILA score0) (p < 0.05). The Quantitative Modified ILD scores in HRCT in RA-indeterminate ILD, RA-mild ILD and RA-advanced ILD groups were significantly different than RA-no ILD (p < 0.001, 0.001 and 0.05, respectively).
  2. §n = 1 patient with UIP.
  3. Ŧn = 2 patients with UIP.
  4. *p < 0.05, ** p < 0.01, *** p < 0.001 when compared with RA-no ILD at baseline; two sample t-test, Mann–Whitney U test (continuous variables) or Chi-square/Fisher’s exact test (categorical variables) were used to calculate p-values.
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