Table 3 Factors predicting radiographic progression in RA-ILD.

From: Predictors of long-term prognosis in rheumatoid arthritis-related interstitial lung disease

 

Progression (n = 19)

No-progression (n = 41)

p-value

Age, years

61.1 ± 16.0

45.1 ± 16.1

0.002

RF, IU/ml

195.0 (122.5–563)*

105.0 (27.4–300.0)

0.044

Anti-CCP, untis/ml

255.0 (81.1–448.1)

274.8 (61.1–500.0)

0.904

DAS28

4.2 (3.3–5)

4.1 (3–5.2)

0.994

Duration of RA, years

3.0 (1.0–10.0)

2.0 (1.0–9.0)

0.542

CXCL9/MIG (log Year 5–log Year 0) *

−0.1 (−0.8–0.3)

−0.3 (−0.7–0.0)

0.215

CXCL10/IP10 (log Year 5–log Year 0) *

−0.8 [−1.3–0.0]

−0.6 [−0.9–(−0.3)]

0.667

CXCL11/I-TAC (log Year 5–log Year 0) *

0.0 [−0.9–0.4]

0.0 (−1.5–0.0)

0.036

MMP13 (log Year 5–log Year 0) *

0.0 (−0.4–0.6)

−0.4 (−0.8–0.0)

0.014

  1. * 56 patients had cytokine analysis at Year 5 (excludes n = 4 progressors who died prior to Year 5 serum collection).
  2. After normality testing (K-S test) for the nine indices, age conformed to a normal distribution. The actual values were presented as mean ± standard deviation. RF, anti-CCP, DSA28 and disease duration at baseline did not adhere to a normal distribution and were therefore converted by logarithm transformation and presented as median values (interquartile range). Changes in cytokine levels of CXCL11/I-TAC and MMP-13 from Year 0 to Year 5 were converted by logarithm transformation and expressed as (log Year 5—log Year 0). Significant differences were found between the progression and the no-progression groups for age, RF, CXCL11/I-TAC (log Year 5—log Year 0) and MMP13 (log Year 5—log Year 0). Other variables did not show statistically significant differences.
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