Figure 2 | Scientific Reports

Figure 2

From: A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis

Figure 2

CR57 and R173 binding and neutralization of rabies glycoproteins. (a) Schematic of rabies glycoprotein showing non-overlapping antigenic sites locations of RAB1 (antigenic site III) and CR57 (antigenic site I), figure was created with BioRender.com. (b, c) ELISA binding of CR57 (b) and R173 (c) to the wild type ERA439 or RAB1 escape mutant N336D R346K. (d, e) Pseudovirus neutralization of RAB1, CR57, and R173 against lentivirus bearing the wild type ERA glycoprotein (d) and N336 R346K mutant (e). EC50 values were calculated by nonlinear regression analysis using Prism version 8.1.1. Data is plotted as the mean ± s.d. from n = 4 independent experiments.

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