Table 2 RFFIT of RAB1, RAB2 and R172 against North America terrestrial isolates.

Viral isolate	Source (location)	Epitope^b	RAB1	RAB2	R172	HRIG
TX Coyote 323R	Coyote (Texas)	ENR	++	+	++	54
AK Fox	Fox (Alaska)	ENR	++	++	++	78
CA SK	Skunk (California)	ENR	++	++	++	48
PR Mong	Mongoose (Puerto Rico)	ENR	++	++	++	86
Sonora Dog	Dog (Mexico)	ENR	++	++	++	50
TXSK 4380	Skunk (Texas)	ENR	++	++	++	175
TXSK 5171	Skunk (Texas)	ENR	++wt	++	++	26
TXSK 5171	Skunk (Texas)	ENR	−^a	++	++	26
ERA	Lab Strain	ENR	++	++	++	67
NCSK	Skunk (North-central US)	ENK	++	++	++	49
TXFX	Fox (Texas)	ENK	++	++	++	40
RAC	Raccoon (Southeast US)	ESR	++	++	++	37
CVS-11	Lab Strain	EDR	+	++	++	25

++EC₅₀ < 1 µg/mL.
+EC₅₀ ≥ 1 µg /mL.
− Not neutralized by HuMAb at the highest concentration tested.
HRIG potency IU/mL against given isolate.
^aLab-acquired mutation I338T identified in TKSK 5171 following additional cell culture passage. A primary wild type (wt) isolate tested.
^bEpitope variants with the noted residues at positions 33, 336, and 346.

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