Table 3 RFFIT of RAB1, RAB2 and R172 against North America bat isolates.

From: A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis

Viral isolate

Source (location)

Epitopeb

RAB1

RAB2

R172

HRIG

DR Brazil

Desmodus rotundus (Brazil)

ENR

++

++

++

34

C1434

Perimyotis subflavus (Alabama)

ENK

++

++

++

40

CO/EF Bat 6938

Eptesicus fuscus/Myotis sp. (Colorado)

ENK

++

++

++

64

WA Bat

Lasionycteris noctivagans (Washington)

ENK

++

++

++

44

AZ Fox 2400

Ef variant in a fox (Arizona)

ENK

++

++

++

139

AZ 3860 Bata

Parastrellus hesperus (Arizona)

ENS

++

++

38

CA Bat

Myotis thysanodes (California)

ENS

++

++

++

10

Myotis

Myotis sp.(Washington)

ENS

++

++

++

26

1625 Bat

Lasiurus borealis (Michigan)

DNE

+

+

+

15

AZ Bat LC

Aeorestes cinereus (Arizona)

DNE

+

+/−

+

10

FL Bat 769

Lasiurus seminolus (Florida)

DNE

+

+/−

6

TN132

Lasiurus borealis (Tennessee)

DNE

+/−

+/−

11

TN269

Lasiurus borealis (Tennessee)

DNE

+/−

+/−

9

TN33

Lasiurus borealis (Tennessee)

DNE

+

+/−

+

9

TN410

Aeorestes cinereus (Tennessee)

DNE

+

+

+

11

VA1340

Lasiurus borealis (Virginia)

DNE

+/−

+/−

8

VA399

Lasiurus borealis (Virginia)

DNE

+

+/−

+

6

Bat EF

Eptesicus fuscus (Pennsylvania)

EDR

++

++

++

46

  1. ++EC50 < 1 µg /mL.
  2. +EC50 > 1 µg /mL.
  3. +/− EC50 > 100 ug/ml.
  4. − Not neutralized by HuMAb at the highest concentration tested.
  5. HRIG potency IU/mL against given isolate.
  6. aLab-acquired mutation I338T identified in 3860 Bat following cell culture adaptation. A primary (wild type) isolate of this virus is not available to test.
  7. bEpitope variants with the noted residues at positions 33, 336, and 346.