Table 4 RFFIT of RAB1, CR57 and R173 against North America terrestrial isolates.

From: A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis

Viral isolate

Source (location)

Epitopeb

RAB1

CR57

R173

HRIG

TXSK 4380

Skunk (Texas)

NR*

++

++wt

++

x

−a

TXSK 5171

Skunk (Texas)

NR*

++wt

++

++

x

−a

CVS-11

Lab Strain

DR

+

++

++

x

  1. ++EC50 < 1 µg/mL.
  2. +EC50 ≥ 1 µg /mL.
  3. − Not neutralized by HuMAb at the highest concentration tested.
  4. x Neutralized by HRIG.
  5. aLab-acquired mutation following additional cell culture passage. A primary wild type (wt) isolate was tested.
  6. bRAB1 epitope variants with the noted residues at positions 336, and 346.
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