Table 5 RFFIT of RAB1, CR57 and R173 against North America bat isolates.

From: A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis

Viral isolate

Source (location)

Epitopeb

RAB1

CR57

R173

HRIG

C1434

Perimyotis subflavus (Alabama)

NK

++

+

++

x

CO/EF Bat 6938

Eptesicus fuscus/Myotis sp. (Colorado)

NK

++

++

++

x

WA Bat

Lasionycteris noctivagans (Washington)

NK

++

++

++

x

AZ 3860 Bata

Parastrellus hesperus (Arizona)

NS

++

++

x

1625 Bat

Lasiurus borealis (Michigan)

NE

+

++

++

x

AZ Bat LC

Aeorestes cinereus (Arizona)

NE

+

++

++

x

FL Bat 769

Lasiurus seminolus (Florida)

NE

+

++

++

x

TN132

Lasiurus borealis (Tennessee)

NE

+

++

++

x

TN269

Lasiurus borealis (Tennessee)

NE

+

++

++

x

TN33

Lasiurus borealis (Tennessee)

NE

+

++

++

x

TN410

Aeorestes cinereus (Tennessee)

NE

+

++

++

x

VA1340

Lasiurus borealis (Virginia)

NE

+

++

++

x

VA399

Lasiurus borealis (Virginia)

NE

+

++

++

x

AL Bat Tb

Tadarida brasiliensis (Alabama)

DR

++

++

x

  1. ++ EC50 < 1 µg /mL.
  2. +EC50 > 1 µg /mL.
  3. − Not neutralized by HuMAb at the highest concentration tested.
  4. x Neutralized by HRIG.
  5. aLab-acquired mutation I338T identified in 3860 Bat following cell culture adaptation. A primary (wild type) isolate of this virus is not available to test.
  6. bRAB1 epitope variants with the noted residues at positions 336, and 346.