Figure 3 | Scientific Reports

Figure 3

From: A desirable transgenic strategy using GGTA1 endogenous promoter-mediated knock-in for xenotransplantation model

Figure 3

Functional hCD55 and hCD39 gene expressed on GTKO/CD55/CD39 pig. (A) Decrease of C3 deposition on RBCs from GTKO/CD55/CD39 compared with RBCs from GTKO pig at 0, 25, and 50% of human complement serum concentration. Experiments were performed in triplicated (n = 1, t-test; *P < 0.05; **P < 0.01; ns, non-significant). (B) Inhibition of platelet aggregation in GTKO/CD55/CD39 pig by platelet aggregation test response to ADP (10 µM) and collagen (2 mg/mL). Experiments were performed in independently triplicated (n = 1, *P value = 0.0169; **P value = 0.0014, one-way analysis of variance).

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