Figure 4
Rab27 DKO mice demonstrate abnormal synaptic terminal ultrastructure. (a) Representative transmission EM images of motor cortex from a wildtype C57BL/6J mouse. Scale bar = 600 nm. Black arrowheads point to synaptic terminals. (b) Representative transmission EM images of motor cortex from a Rab27 DKO mouse with the chromosome 6 deletion involving Snca and Mmrn1. Scale bar = 600 nm. Black arrows point to abnormal synaptic terminals. Gray arrowheads point to membrane-less structures not observed in wildtype mice. (c) Quantification of synaptic vesicle number, bouton area, and synaptic vesicle density in motor cortices from wildtype C57BL/6J and Rab27 DKO mice with the chromosome 6 deletion involving Snca and Mmrn1. n = 18 synapses for control and 42 synapses for Rab27 DKO. *p < 0.05, ****p < 0.0001 (unpaired, two-tailed t test).
