Figure 6
WNT3 results. Display of TaqMan assay arrangement on a schematic image of WNT3 (note: size ratio of exons to each other is not accurate), baselines and differential gene expression after 0.5 Gy and 4 Gy after 24 h and 48 h. At the bottom of the figure, the inter-individual variability is shown. The assay with the lowest sum of the standard deviation of the FCs over all dose categories is ranked 1st. Correspondingly the assay with the highest sum is ranked last. Starting with the baseline and working downwards, the assays meeting the criteria defined in the material and methods are circled. For illustration, the inter-individual variability of the TaqMan assays identified using the other criteria (baseline, dose dependency, time persistency) are circled in orange. The two encircled assays on the schematic image of WNT3 are the ones most suitable for biodosimetry purposes. Asterisks mark the best coverage assay. Data from only one donor, for the other two donors the assay was not detectable1.
