Figure 1 | Scientific Reports

Figure 1

From: An approach to cellular tropism of SARS-CoV-2 through protein–protein interaction and enrichment analysis

Figure 1

Research strategy. 1: (a) Obtaining the PPI of the SARS-CoV-2—Human (V-H) from IMEx; 2: Integration of human-specific PPIs from 7 primary databases (H–H); 3: Obtaining proteomes and transcriptomes, selecting those results that are reported at both levels; 4: Generation of human PPI (H–H) for each cell; 5: Obtaining the PPI of the viral infection (V-H–H) of each cell. Images were taken from https://www.imexconsortium.org/, https://dip.doe-mbi.ucla.edu/dip/Main.cgi, https://www.ebi.ac.uk/intact/, https://mint.bio.uniroma2.it/, https://thebiogrid.org/, https://www.hprd.org/, http://matrixdb.univ-lyon1.fr/, https://reactome.org/ and . (b) Tissues and cells that shared a set of the seven cell entry proteins/genes. For six cell types there are no reports at the tissue level (transcriptome) and for 23 tissues no cells are reported (proteome).

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