Figure 5
Specific networks. (a,b) ribosome pathway networks: (c,d) networks of the ribosome synthesis pathway. Lung (macrophages and pneumocytes), respectively. The color code and size nodes are the same as in Fig. 3. In the ribosome pathway there are 11 viral proteins (N, nsp4, PL-PRO, nsp2, nsp8, nsp13, orf9c, S, nsp1, orf10, and nsp15) that interact with proteins of this pathway. In Ribosome biogenesis in eukaryotes pathway there are 16 viral proteins (nsp7b, N, orf7a, nsp4, nsp2, nsp8, nsp13, nsp7, orf8, nsp10, orf9c, M, orf6, orf10, nsp15, and orf3a) that interact with proteins in this pathway; among them the 3 proteins with a high connectivity of SARS-CoV-2: M, nsp7b, and orf3a. These data are for the 2 cells shown. Similar results for kidney (cells in tubules) and small intestine (glandular cells) are present in Supplementary Fig. S7.
