Figure 7
Structural depiction of prohibitin-1, CHIKV envelope glycoprotein E1-E2 heterodimer and their docked conformations. (a) Model structure of prohibitin ectodomain, generated using the SWISS-MODEL software54. The protein is depicted in cartoon presentation of protein backbone (cyan), showing the N-terminal prohibitin (PHB) and C-terminal coiled coil domains. (b) Front view of the docked conformations of prohibitin and CHIKV E1-E2 heterodimer. The E1 and E2 subunits are depicted in surface presentation with green and blue color schemes, respectively. The first and third docked conformations of prohibitin are shown in cartoon presentation in magenta and yellow color schemes. (c) The top view of the docked conformations of prohibitin and CHIKV E1-E2 heterodimer. (d) The close-up of the front view of the docked conformations of prohibitin and CHIKV E1–E2 heterodimer. These diagrams have been prepared using the molecular visualization system PyMOL47.
