Figure 6
From: Immuno-reactive cancer organoid model to assess effects of the microbiome on cancer immunotherapy
The effects of bacterial metabolites and ICB combinations on immune cell cytotoxicity in iTOs (a–c) CD8 (a), Granzyme B (b), and cleaved caspase-3 signals (c) normalized to DAPI signal in iTOs (n = 4 ROI). (d) Viability of the CD8+ immune cell population in the different metabolite treated samples, all samples treated with ICB (data representative of 3 organoids combined).
