Figure 4
Metabolites’ steady state solutions. Here we show the time series resulting from numerically solving the system of differential Eqs. (1)–(11) for 500 min under healthy conditions, i.e., using the parameters and initial conditions of Table 1. Individual panels correspond to every node (metabolite) depicted in the network of Fig. 2, which is modeled by the differential Eqs. (1)–(11). Blue lines represent the concentration of the corresponding metabolite in time. After a short transient, or settling time, every metabolite reaches a feasible steady state. We refer to this steady state concentration as the healthy concentration or the healthy case, as it represents a qualitative baseline for analysing how the system responds to perturbations.
