Table 1 Parameters and initial conditions for the numerical simulations under healthy conditions.
Parameter | Value | Source | Parameter | Value | Source |
|---|---|---|---|---|---|
G | 5 mM | +54 | \(\lambda _E\) | 0.8 mM\(^{-1}\) | \(\circ\) |
\(V_{\mathrm{max}_{[\text{g}_E]}}\) | 1.2 mM min\(^{-1}\) | +55 | \(\lambda _{LACT_E}\) | 480 mM\(^{-1}\) | \(\circ\) |
\(K_{m_{[\text{g}_E]}}\) | 9 mM | \(\lambda _r\) | 21.7E−3 mM\(^{-1}\) | \(\circ\) | |
\(V_{\mathrm{max}_{[\text{G6P}_{E}]}}\) | 0.00738 mM min\(^{-1}\) | – | \(\psi _{[\text{PYR}_E]}\) | 710 min\(^{-1}\) | \(\circ\) |
\(K_{m_{[\text{G6P}_{E}]}}\) | 0.002844 mM | – | \(\psi _{[\text{NADPH}_r]}\) | 15E2 min\(^{-1}\) | + |
\(V_{\mathrm{max}_{[\text{g}_r]}}\) | 0.8 mM min\(^{-1}\) | \(\psi _{[\text{LACT}_r]}\) | 96E2 min\(^{-1}\) | \(\circ\) | |
\(K_{m_{[\text{g}_r]}}\) | 8 mM | \(\psi _{[\text{G3P}_r]}\) | 0.02 min\(^{-1}\) | + | |
\(V_{\mathrm{max}_{[\text{F16BP}_E]}}\) | 1.2285 mM min\(^{-1}\) | \(\diamond\) +56 | [GLUT1] | 1 | \(\circ\) |
\(K_{m_{[\text{F16BP}_E]}}\) | 0.1106 mM | – | \(c_{M1}\) | 1 | \(\circ\) |
\(V_{\mathrm{max}_{[\text{PYR}_E]}}\) | 0.00783 mM min\(^{-1}\) | – | \(\delta _r\) | 13E8 | \(\circ\) |
\(K_{m_{[\text{PYR}_E]}}\) | 0.17 mM | – | [PYR\(_E\)*] | 4.6E−5 mM | \(\circ\) |
\(V_{\mathrm{max}_{[\text{PYR}_rE]}}\) | 14 mM min\(^{-1}\) | – | [PEP*] | 1.65E−13 mM | \(\circ\) |
\(K_{m_{[\text{PYR}_rE]}}\) | 0.125 mM | * | \(q_r\) | 0.18 | + |
\(V_{\mathrm{max}_{[\text{F16BP}_r]}}\) | 1.365 mM min\(^{-1}\) | +56 | \(\rho _r\) | 1E−3 | +54 |
\(K_{m_{[\text{F16BP}_r]}}\) | 3.5 mM | +56 | [g\(_r\)]\(_0\) | 0.1 mM | – |
\(V_{\mathrm{max}_{[\text{G6P}_{r}]}}\) | 0.1845 mM min\(^{-1}\) | +57 | [G6P\(_r\)]\(_0\) | 0.45 mM | + |
\(K_{m_{[\text{G6P}_{r}]}}\) | 0.09 mM | +54 | [F16BP\(_r\)]\(_0\) | 0.06 mM | + |
\(V_{\mathrm{max}_{[\text{NADPH}_{r}]}}\) | 0.228 mM min\(^{-1}\) | +58 | [NADPH\(_r\)]\(_0\) | 0.1E−8 mM | – |
\(K_{m_{[\text{NADPH}_{r}]}}\) | 0.45 mM | +58 | [PYR\(_r\)]\(_0\) | 0 mM | |
\(V_{\mathrm{max}_{[\text{PYR}_r]}}\) | 0.3915 mM min\(^{-1}\) | +57 | [LACT\(_r\)]\(_0\) | 1E−4 mM | + |
\(K_{m_{[\text{PYR}_r]}}\) | 0.06 mM | [G3P\(_r\)]\(_0\) | 2.5E−6 mM | + | |
\(V_{\mathrm{max}_{[\text{G3P}_r]}}\) | 0.15 mM min\(^{-1}\) | +54 | [g\(_E\)]\(_0\) | 3 mM | + |
\(K_{m_{[\text{G3P}_r]}}\) | 0.143 mM | +54 | [G6P\(_E\)]\(_0\) | 5E−3 mM | – |
\(V_{\mathrm{max}_{[\text{LACT}_r]}}\) | 0.14 mM min\(^{-1}\) | + | [F16BP\(_E\)]\(_0\) | 0.13 mM | – |
\(K_{{m}_[\text{LACT}_r]}\) | 1.25E−5 mM | – | [PYR\(_E\)]\(_0\) | 0 mM |
