Table 4 Median [interquartile range] time of treatments in three major outcomes of 13 toxicology referral centers during early Iranian methanol outbreak.

From: A cross-sectional multicenter linkage study of hospital admissions and mortality due to methanol poisoning in Iranian adults during the COVID-19 pandemic

Time of Treatment (min)

East Azarbayjan (n = 140)

Gilan (n = 28)

Hamedan (n = 7)

Isfahan (n = 52)

Khorasan Razavi (n = 56)

Khuzestan (n = 75)

Mazandaran (n = 5)

Qazvin (n = 3)

Tehran (n = 316)

West Azarbayjan (n = 4)

Yazd (n = 30)Yazd (n = 30)

P value

Total (n = 716)

Death (n = 84)

Buffer

n (%)

15/19 (79)

1/11 (9)

1/1 (100)

3/5 (60)

0/1 (0)

7/7 (100)

3/3 (100)

1/1 (100)

18/35 (51)

1/1 (100)

0

–

50/84 (60)

Ingestion to tx

1445 [1445, 2885]

2880 [–, –]

450 [–, –]

1500 [1500, –]

–

2885 [2885, 4325]

1480 [1530, –]

1500 [–, –]

1445 [1391, 2885]

4320 [–, –]

–

0.182*

1515 [1445, 2885]

n (%)

18/19 (95)

1/11 (9)

1/1 (100)

4/5 (80)

1/1 (100)

7/7 (100)

3/3 (100)

1/1 (100)

26/35 (74)

1/1 (100)

0

–

62/84 (74)

Arrival to tx

5 [5, 5]

1440 [–, –]

30 [–, –]

150 [75, 225]

5 [–, –]

5 [5, 5]

40 [5, –]

60 [–, –]

5 [5, 128]

2160 [–, –]

–

 < 0.001*

5 [5, 60]

Ethanol

n (%)

15/19 (79)

0/11 (0)

1/1 (100)

4/5 (80)

0/1 (0)

0/7 (0)

3/3 (100)

0/1 (0)

19/35 (54)

0/1(0)

0

–

42/84 (50)

Ingestion to tx

1445 [1445, 2885]

–

440 [–, –]

1665 [1500, 1920]

–

–

1530 [1680, –]

–

1445 [1445, 2885]

–

–

0.282*

1472 [1445, 2345]

n (%)

18 (95)

0/11 (0)

1/1 (100)

5 (100)

1/1 (100)

0/7 (0)

3/3 (100)

0/1 (0)

27/35 (77)

0/1(0)

0

–

54/84 (64)

Arrival to tx

5 [5, 5]

–

20 [–, –]

60 [30, 135]

5 [–, –]

–

5 [90, –]

–

5 [5, 210]

–

–

0.001*

5 [5, 60]

Follinic acid

n (%)

15/19 (79)

0/11 (0)

1/1 (100)

3/5 (60)

0/1 (0)

6/7 (86)

3/3 (100)

0/1 (0)

16 (46)

1/1 (100)

0

–

45/84 (54)

Ingestion to tx

1445 [1445, 2885]

–

1860 [–, –]

1860 [1440, –]

–

2885 [2885, 4325]

114 [35, –]

–

1472 [1445, 2733]

4440 [–, –]

–

0.242*

1740 [1445, 2885]

n (%)

15/19 (79)

0/11 (0)

1/1 (100)

4/5 (80)

1/1 (100)

6/7 (86)

3/3 (100)

0/1 (0)

23/35 (66)

1/1 (100)

0

–

56/84 (67)

Arrival to tx

5 [5, 5]

–

1440 [–, –]

108 [75, 375]

5 [–, –]

5 [5, 5]

90 [5, –]

–

60 [5, 300]

2280 [–, –]

–

 < 0.001*

5 [5, 165]

Hemodialysis

n (%)

13/19 (68)

1/11 (9)

1/1 (100)

3/5 (60)

0/1 (0)

6/7 (86)

2/3 (67)

1/1 (100)

22/35 (63)

1/1 (100)

0

–

48/84 (57)

Ingestion to tx

1500 [1490, 3060]

1445 [–, –]

1320 [–, –]

1590 [2040,–]

–

3150 [2685, 4515]

1580 [1937, –]

1620 [–, –]

1515 [1486, 2955]

4560 [–, –]

–

0.074*

1605 [1500, 3000]

n (%)

11/19 (58)

1/10 (10)

1/1 (100)

3/5 (60)

1/1 (100)

6/7 (86)

2/3 (67)

1/1 (100)

30 (86)

1/1 (100)

0

–

59/84 (70)

Arrival to tx

60 [60, 135]

60 [–, –]

900 [–, –]

540 [270, –]

600 [–, –]

180 [165, 270]

318 [140, –]

180 [–, –]

60 [60, 128]

2400 [–, –]

–

0.002*

120 [60, 240]

Survival without sequelae (n = 492)

Buffer

n (%)

93/105 (89)

0/10 (0)

2/6 (33)

33/37 (89)

15 /38 (39)

19/66 (29)

1/1 (100)

0/2 (0)

130/212 (61)

1/1 (100)

0/14 (0)

–

279/492 (55)

Ingestion to tx

2885 [1445, 2885]

–

5415 [390, –]

2220 [1200, 2670]

2885 [1445, 2885]

2885 [1445, 2885]

2990 [–, –]

–

2885 [1445, 2885]

2220 [–, –]

–

0.474*

2885 [1445, 2885]

n (%)

93/105 (90)

0/10 (0)

2/6 (33)

37/37 (100)

25 /38 (66)

19/66 (29)

1/1 (100)

0/2 (0)

131/212 (62)

1/1 (100)

0/14 (0)

–

285/492 (58)

Arrival to tx

5 [5, 5]

–

30 [195, –]

60 [30, 120]

5 [5, 5]

5 [5, 5]

30 [–, –]

–

5 [5, 5]

60 [–, –]

–

 < 0.001*

5 [5, 5]

Ethanol

n (%)

102/105 (97)

0/10 (0)

1/6 (17)

32/37 (86)

16 /38 (42)

0/66 (0)

1/1 (100)

0/2 (0)

165/212 (78)

0/1 (0)

0/14 (0)

–

301/492 (61)

Ingestion to tx

2885 [1445, 2885]

–

390 [–, –]

2235 [1155, 2550]

2885 [1445, 2885]

–

2990 [–, –]

–

2885 [1445, 2885]

–

–

0.094*

2790 [1445, 2885]

n (%)

103/105 (98)

0/10 (0)

1/6 (17)

36/37 (97)

28 /38 (74)

0/66 (0)

1/1 (100)

0/2 (0)

166/212 (78)

0/1 (0)

0/14 (0)

–

307/492 (62)

Arrival to tx

5 [5, 5]

–

30 [–, –]

60 [30, 120]

5 [5, 5]

–

30 [–, –]

–

5 [5, 5]

–

–

 < 0.001*

5 [5, 5]

Follinic acid

n (%)

103/105 (98)

0/10 (0)

0/6 (0)

21/37 (57)

0 /38 (0)

15/66 (23)

1/1 (100)

0/2 (0)

162/212 (76)

1/1 (100)

0/14 (0)

–

303/492 (62)

Ingestion to tx

2885 [1445, 2885]

–

–

1980 [1095, 2850]

2885 [1445, 2885]

2885 [1445, 2885]

6480 [–, –]

–

2885 [1500, 3151]

2220 [–, –]

–

0.092*

2885 [1445, 2885]

n (%)

104/105 (99)

0/10 (0)

0/6 (0)

25/37 (68)

0 /38 (0)

15/66 (23)

1/1 (100)

0/2 (0)

163/212 (77)

1/1 (100)

0/14 (0)

–

309/492 (63)

Arrival to tx

5 [5, 5]

–

–

150 [90, 330]

5 [5, 5]

5 [5, 5]

4320 [–, –]

–

5 [5, 540]

60 [–, –]

–

 < 0.001*

5 [5, 5]

Hemodialysis

n (%)

93/105 (90)

1/10 (10)

1/6 (17)

28/37 (76)

15/38 (39)

16/66 (24)

1/1 (100)

0/2 (0)

185/212 (87)

1/1 (100)

0/14 (0)

–

341/492 (69)

Ingestion to tx

2925 [1530, 2970]

3120 [–, –]

690 [–, –]

2580 [1485, 2940]

3180 [2160, 3600]

3000 [1560, 3210]

2280 [–, –]

–

2220 [1560, 3030]

2760 [–, –]

–

0.072*

2885 [1560, 3000]

n (%)

94/105 (90)

1/10 (10)

1/6 (17)

31/37 (84)

24/38 (63)

16/66 (24)

1/1 (100)

0/2 (0)

186/212 (88)

1/1 (100)

0/14 (0)

–

355/492 (72)

Arrival to tx

60 [49, 90]

240 [–, –]

330 [–, –]

360 [240, 420]

630 [375, 720]

150 [120, 240]

120 [–, –]

–

120 [90, 180]

600 [–, –]

–

 < 0.001*

120 [60, 240]

Survival with sequelae (n = 140)

Buffer

n (%)

15/16 (94)

0/7 (0)

0/7 (0)

7/10 (70)

10/17 (59)

2/2 (100)

1/1 (100)

0

33/69 (48)

1/1 (100)

0/16 (0)

–

59/140 (42)

Ingestion to tx

1445 [1445, 2885]

–

–

2520 [1470, 4320]

2885 [995, 2885]

2885 [2885, 2885]

2220 [–, –]

–

2885 [1500, 3300]

2940 [–, –]

 

0.181*

2885 [1450, 3060]

n (%)

15/16 (94)

0/7 (0)

0/7 (0)

9/10 (90)

17/17 (100)

2/2 (100)

1/1 (100)

0

35/69 (51)

1/1 (100)

0/16 (0)

–

63/140 (45)

Arrival to tx

5 [5, 5]

–

–

30 [23, 120]

5 [5, 5]

5 [5, 5]

780 [–, –]

–

30 [5, 360]

1500 [–, –]

 

 < 0.001*

5 [5, 82]

Ethanol

n (%)

16/16 (100)

0/7 (0)

0/7 (0)

7/10 (70)

10/17 (59)

0/2 (0)

0/1 (0)

0

39/69 (57)

1/2 (50)

0/16 (0)

–

63/140 (45)

Ingestion to tx

1445 [1445, 2885]

–

–

2430 [1500, 4320]

2885 [995, 2885]

–

–

–

2885 [1560, 3240]

2940 [–, –]

–

0.039*

2885 [1470, 3060]

n (%)

16/16 (100)

0/7 (0)

0/7 (0)

9/10 (90)

14/17 (82)

0/2 (0)

0/1 (0)

0

39/69 (57)

1/2 (50)

0/16 (0)

–

65/140 (46)

Arrival to tx

5 [5, 5]

–

–

60 [30, 330]

5 [5, 5]

–

–

–

30 [5, 180]

1500 [–, –]

–

 < 0.001*

5 [5, 90]

Follinic acid

n (%)

16/16 (100)

1/7 (43)

1/7 (14)

6/10 (60)

10/17 (59)

2/2 (100)

0/1 (0)

0

39/69 (57)

1/2 (50)

0/16 (0)

–

65/140 (46)

Ingestion to tx

1445 [1445, 2885]

2160 [–, –]

2160 [–, –]

2295 [1500, 3495]

2885 [995, 2885]

2885 [2885, 2885]

–

–

2885 [1560, 3360]

2940 [–, –]

–

0.158*

2885 [1450, 3060]

n (%)

16/16 (100)

1/7 (43)

1/7 (14)

7/10 (70)

16/17 (94)

2/2 (100)

0/1 (0)

0

40/69 (58)

1/2 (50)

0/16 (0)

–

67/140 (48)

Arrival to tx

5 [5, 5]

1080 [–, –]

1080 [–, –]

180 [60, 300]

5 [5, 5]

5 [5, 5]

–

 

75 [5, 420]

1500 [–, –]

–

 < 0.001*

5 [5, 120]

Hemodialysis

n (%)

14/16 (88)

 

3/7 (43)

6/10 (60)

10/17 (59)

2/2 (100)

1/1 (100)

0

53/69 (77)

1/2 (50)

0/16 (0)

–

90/140 (64)

Ingestion to tx

1860 [1495, 2948]

3060 [3000–, –]

3000 [3060, –]

2640 [1621, 5325]

3450 [1800, 3765]

3060 [3000,–]

2340 [–, –]

–

2940 [1860, 3270]

3180 [–, –]

 

0.419*

2885 [1470, 3030]

n (%)

14/16 (88)

1/7 (43)

3/7 (43)

8/10 (80)

16/17 (94)

2/2 (100)

1/1 (100)

0

55/69 (80)

1/2 (50)

0/16 (0)

–

100/140 (71)

Arrival to tx

60 [40, 120]

180 [120, –]

180 [120, –]

240 [195, 690]

660 [420, 885]

180 [120, –]

900 [–, –]

–

120 [30, 300]

1740 [–, –]

–

 < 0.001*

120 [60, 420]

  1. ND not defined, missing data treated by random.
  2. *Applying Kruskal Wallis test.
  3. †applying Pearson Chi–Square.
  4. ‡Applying Man–Whitney U–test.
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