Figure 1
From: Thermal gradient ring reveals thermosensory changes in diabetic peripheral neuropathy in mice
Changes in blood glucose levels, body weight, and serum insulin levels after administering STZ. (a) Changes in blood glucose levels before and after intraperitoneal injection of streptozotocin (STZ 150 mg/kg) or 0.02 M citrate buffer (pH 4.5) in 5-week-old wild-type mice (diabetes mellitus (WT (non-DM)), n = 10; non diabetic (WT (non-DM)), n = 10). (b) Changes in body weight of the same mice are shown in (a,c). Comparison of serum insulin levels of WT (DM) and WT (non-DM) mice at 10 weeks old (WT (DM), n = 6; WT (non-DM), n = 8). Open circles indicate each insulin level. Timing for STZ and the buffer administration is indicated by arrows. The data are presented as the means ± SEM. Two-way repeated measures ANOVA followed by a Bonferroni post hoc test (a,b) and a two-tailed t test (c) was used for comparison. **p < 0.01, ***p < 0.001 vs. WT (non-DM).
