Figure 2
From: Thermal gradient ring reveals thermosensory changes in diabetic peripheral neuropathy in mice
Changes in paw withdrawal latency in WT (DM), TRPV1−/− (non-DM) and TRPA1−/− (non-DM) mice. (a,b) Changes in paw withdrawal latency (PWL) by IR intensity 40 (a) and IR intensity 20 (b) before and after intraperitoneal injection of streptozotocin (STZ 150 mg/kg) or an equal volume of citrate-buffer vehicle in 5-week-old wild-type mice (diabetic mellitus (WT (DM)), n = 8–9; non-diabetic (WT (non-DM)), n = 10). (c) Comparison of PWL by IR intensity 40 in WT (DM) (n = 9), TRPV1−/− (non-DM) (n = 10), and TRPV1−/− ( DM) (n = 8) mice. (d) Comparison of PWL by IR intensity 40 in WT (DM) (n = 9), TRPA1−/− (non-DM) (n = 9), TRPA1−/− (DM) (n = 8) mice. The PWL at 5 weeks of age was measured a few days before STZ and the buffer administration. Timing for STZ and the buffer administration is indicated by arrows. The data are presented as box-and-whisker plots. Two-way repeated measures ANOVA followed by a Bonferroni post hoc test. *p < 0.05, **p < 0.01, ***p < 0.001 vs. DM.
