Table 4 Top candidate genes after applying the prioritization criteria.
Gene score | Phenotype | Chr | Positional candidate gene | Type of mutation | P-value liver | FC liver (S1/B6N) |
|---|---|---|---|---|---|---|
12 | Liver weight | 1 | Astn1 | Deleterious domain missense, CTCF binds, UTRs, enhancer and promoter variant | 0.66493 | − 0.03 |
10 | 1 | Sec16b | Deleterious missense, CTCF binds, UTRs, enhancer and promoter variant | 0.54953 | − 0.01 | |
13 | Body weight, | 3 | Frem2 | Deleterious domain missense, CTCF binds, UTRs, enhancer and promoter variant | 0.02092 | 0.12 |
12 | scAT weight, | 3 | Bbs7 | Tolerated domain missense, CTCF binds, UTRs, enhancer and promoter variant | 0.01346 | − 0.14 |
12 | BMI | 3 | Noct | Tolerated domain missense, CTCF binds, UTRs, and promoter variant | 0.00876 | − 0.17 |
10 | Body weight | 6 | Met | Tolerated domain missense, CTCF binds, UTRs, and enhancer variant | 8.20E−06 | − 0.1 |
9 | 6 | Ica1 | CTCF binds, UTRs, enhancer and promoter variant | 0.002 | − 0.15 | |
16 | Liver TG | 8 | Fto | Tolerated domain missense, stop gained, CTCF binds, UTRs, enhancer and promoter variant | 0.01092 | − 0.09 |
13 | 8 | Lpcat2 | Deleterious domain missense, CTCF binds, UTRs, enhancer and promoter variant | 0.22981 | − 0.05 |
