Figure 3
From: Smurf2 inhibition enhances chemotherapy and radiation sensitivity in non-small-cell lung cancer
Combined treatment with bortezomib, cisplatin and radiation results in enhanced DNA damage, cell cycle arrest and enhanced apoptosis in NSCLC cells. Smurf2 inhibition with bortezomib significantly enhanced DNA damage, as shown by the significantly increased percentage of γ-H2AX-positive NSCLC cells after treatment with bortezomib plus cisplatin or radiation compared to treatment with bortezomib, cisplatin, or radiation alone (A). In PC9 cells, combined treatment with bortezomib plus cisplatin plus radiation induced G2/M-phase arrest (B), which was associated with increased apoptosis (C).
