Table 1 Overall and disease-free survival in patients with stage III squamous NSCLC.

From: Smurf2 inhibition enhances chemotherapy and radiation sensitivity in non-small-cell lung cancer

Variable

Reference

Overall survival

Disease-free survival

P value

HR

95% CI

P

Value

HR

95% CI

Lower

Upper

Lower

Upper

Age

 

0.40

1.02

0.98

1.06

0.77

0.99

0.95

1.04

Sex (Female)

Male

0.24

0.65

0.32

1.33

0.32

0.66

0.29

1.51

Race

White

0.41

   

0.07

   

Asian

 

0.29

2.99

0.39

22.71

0.28

3.11

0.40

23.91

Black

 

0.58

1.36

0.47

3.94

0.22

1.88

0.69

5.11

NA

 

0.30

0.69

0.34

1.395

0.06

0.36

0.12

1.04

T stage

T1-T2

0.61

   

0.23

   

T3

 

0.51

1.26

0.63

2.51

0.09

2.02

0.90

4.54

T4

 

0.33

1.46

0.68

3.14

0.26

1.79

0.66

4.87

N stage

N0

0.47

   

0.46

   

N1

 

0.25

1.74

0.68

4.42

0.48

1.44

0.53

3.95

N2

 

0.76

1.16

0.46

2.95

0.64

0.78

0.28

2.22

N3

 

0.34

2.20

0.43

11.28

0.98

0.00

0.00

 

Surgical margin

R0

0.44

   

0.23

   

R1-R2

 

0.22

2.15

0.64

7.18

0.89

0.87

0.12

6.54

RX

 

0.90

0.95

0.42

2.14

0.09

1.98

0.90

4.36

Adjuvant targeted therapy

None

0.28

   

0.25

   

Yes

 

0.18

0.45

0.14

1.44

0.19

0.51

0.18

1.40

NA

 

0.90

1.05

0.51

2.15

0.12

0.54

0.25

1.18

Radiation therapy

T1-T2

0.40

   

0.63

   

Yes

 

0.97

1.01

0.51

2.01

0.77

1.11

0.55

2.26

NA

 

0.20

1.71

0.76

3.85

0.39

0.41

0.05

3.10

Smurf2 expression

Quartile 1

0.01

   

0.05

   

Quartile 2

 

0.01

3.47

1.28

9.38

0.35

1.69

0.56

5.08

Quartile 3

 

0.07

2.37

0.93

6.01

0.47

1.47

0.52

4.10

Quartile 4

 

0.001

5.20

1.93

13.96

0.008

3.77

1.41

10.07

  1. R0, R1, R2, and RX surgical margins: no microscopic residual tumor, microscopic residual tumor, macroscopic residual tumor, and unknown residual tumor status, respectively. HR: hazard ratio. CI: confidence interval. NA: not applicable.
  2. Bold text indicates statistical significance.
Back to article page