Table 2 Characteristics of all 10 liposome formulations produced by lipid-film hydration.

From: Development of a rapid in vitro pre-screen for distinguishing effective liposome-adjuvant delivery systems

Liposome formulation

Mean size (nm) ± SEM

Mean PI

Mean ZP (mV)

DDA:TDB

592 ± 22

0.3

50

DDA:DSPC:TDB

851 ± 21

0.4

53

DDA:DSPC:TDB (50%)

1202 ± 29

0.4

58

DSPC:TDB

1758 ± 79

0.3

-15

DOTAP:TDB

553 ± 24

0.3

58

DC-CHOL:TDB

230 ± 5

0.3

45

DDA alone

453 ± 5

0.3

56

DDA:TDB:PEG25%

286 ± 2.1

0.3

20

DDA:CHOL18:TDB

613 ± 9.1

0.3

52

DDA:CHOL31:TDB

706 ± 8.2

0.3

51

  1. Liposomes (DDA:TDB, DDA:DSPC:TDB, DDA:DSPC:TDB (50%), DSPC:TDB, DOTAP:TDB, DC-CHOL:TDB, DDA, DDA:TDB:PEG(25%), DDA:CHOL18:TDB and DDA:CHOL31:TDB) were produced via lipid film hydration, the lipid suspension was vortexed to produce multi-lamellar vesicles. Liposome characteristics; size (nm), polydispersity index (PI) and zeta potential (ZP) were measured using a Brookhaven ZetaPlus instrument. Results shown for n ≥ 3 (mean ± SEM).
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