Table 3 Correlations between NTN4 and gene markers of immune cells.
From: NTN4 as a prognostic marker and a hallmark for immune infiltration in breast cancer
Cell type | Gene marker | None | Purity | ||
|---|---|---|---|---|---|
Cor | P | Cor | P | ||
B cell | CD19 | − 0.076 | 1.17e−02* | − 0.195 | 5.45e−10*** |
CD20 | 0.011 | 7.05e−01 | − 0.096 | 2.56e−03** | |
CD38 | − 0.152 | 4.25e−07*** | − 0.262 | 3.98e−17*** | |
CD8+ T cell | CD8A | 0 | 1e + 00 | − 0.122 | 1.08e−04*** |
CD8B | − 0.04 | 1.87e−01 | − 0.153 | 1.27e−06*** | |
Tfh cell | CXCR5 | 0.013 | 6.7e−01 | − 0.095 | 2.73e−03** |
ICOS | − 0.109 | 3.12e−04*** | − 0.226 | 5.61e−13*** | |
BCL-6 | 0.322 | 5.55e−28*** | 0.309 | 2.31e−23*** | |
Th1 cell | IL12RB2 | − 0.235 | 2.98e−15*** | − 0.292 | 4.65e−21*** |
WSX-1 | 0.027 | 3.67e−01 | − 0.049 | 1.26e−01 | |
T-BET | − 0.05 | 9.77e−02 | − 0.189 | 1.81e−09*** | |
Th2 cell | CCR3 | 0.058 | 5.32e−02 | 0.004 | 9.05e−01 |
STAT6 | 0.355 | 4.21e−34*** | 0.333 | 3.18e−27*** | |
GATA3 | 0.332 | 1.12e−29*** | 0.396 | 1.14e−38*** | |
Th9 cell | TGFBR2 | 0.388 | 9e−41*** | 0.351 | 3.97e−30*** |
IRF4 | − 0.032 | 2.86e−01 | − 0.16 | 4.30e−07*** | |
PU.1 | 0.033 | 2.71e−01 | − 0.06 | 3.86e−02* | |
Th17 cell | IL-21R | 0.001 | 9.67e−01 | − 0.114 | 3.16e−04*** |
IL-23R | 0.051 | 9.21e−02 | − 0.012 | 7.08e−01 | |
STAT3 | 0.436 | 3.96e−52*** | 0.415 | 1.10e−42*** | |
Th22 cell | CCR10 | 0.001 | 9.69e−01 | − 0.051 | 1.09e−01 |
AHR | 0.475 | 4.58e−63*** | 0.432 | 1.93e−46*** | |
Treg cell | FOXP3 | − 0.085 | 4.97e−03** | − 0.179 | 1.38e−08*** |
CCR8 | − 0.069 | 2.12e−02* | − 0.135 | 1.88e−05*** | |
CD25 | − 0.165 | 3.8e−08*** | − 0.273 | 1.86e−18*** | |
T cell exhaustion | PD-1 | − 0.122 | 5.08e−05*** | − 0.261 | 6.15e−17*** |
CTLA4 | − 0.16 | 9.97e−08*** | − 0.283 | 8.12e−20*** | |
Macrophage | CD68 | 0.03 | 3.22e−01 | − 0.044 | 1.70e−01 |
CD11b | 0.255 | 7.54e−18*** | 0.191 | 1.28e−09*** | |
M1 | NOS2 | − 0.013 | 6.69e−01 | − 0.014 | 6.68e−01 |
ROS1 | − 0.068 | 2.34e−02* | − 0.084 | 8.35e−03** | |
M2 | ARG1 | 0.016 | 6.02e−01 | −0.005 | 8.80e−01 |
MRC1 | 0.067 | 2.68e−02* | − 0.023 | 4.71e−01 | |
TAM | HLA-G | − 0.036 | 2.27e−01 | − 0.103 | 1.09e−03** |
CD80 | − 0.025 | 4.16e−01 | − 0.093 | 3.43e−03** | |
Monocyte | CD14 | − 0.001 | 9.63e−01 | − 0.079 | 1.32e−02* |
CD16 | 0.103 | 6.21e−04*** | 0.045 | 1.53e−01 | |
NK | XCL1 | − 0.021 | 6.86e−01 | − 0.12 | 1.46e−04*** |
KIR3DL1 | − 0.052 | 8.35e−02 | − 0.13 | 4.11e−05*** | |
CD7 | − 0.127 | 2.36e−05*** | − 0.27 | 4.58e−18*** | |
Neutrophil | CD15 | 0.069 | 2.24e−02* | − 0.012 | 6.98e−01 |
MPO | 0.023 | 4.38e−01 | − 0.023 | 4.75e−01 | |
DC | CD1C | 0.235 | 3.29e−15*** | 0.16 | 4.03e−07*** |
CD141 | 0.415 | 4e−47*** | 0.381 | 1.21e−35*** | |
