Figure 4

Photomicrograph showing the ulcerative colonic mucosa photomicrograph from the colon mucosa of, (a,b) negative control rats showing normal mucosa (black line) (a) and normal lamina propria containing few eosinophils (black thin arrows) as well as normal crypts lined by mucin-secreting cells (red thick arrows) (b), (c,d) C+ ve showing diffuse ulcerative colitis with diffuse necrosis and desquamation of mucosal epithelium (black line) and crypts which are intensely infiltrated by neutrophils (astrix) (c) in addition to severe congestion of mucosal blood vessels (black arrows) and aggregation of bacterial colonies (red arrows) (d), (e,f) Prednisolone treated group showing small focal ulcerative lesions (black line) with focal necrosis and desquamation of mucosal epithelium (red arrows) (e) and few proprial hemorrhage (black arrows) (f), (g,h) Leave (250 mg/kg)group showing diffuse necrosis of colonic mucosa(black line) associated with severe congestion of mucosal blood vessels(black arrows) (g) and massive neutrophilic cell infiltration (red arrows) (h), (i,j) the Leave (500 mg/kg)group showing large focal erosive lesion (red arrows) (i) and few proprial hemorrhage (black arrows) (j), (k,l) Stem (250 mg/kg) group showing normal mucosal epithelium (black arrows) (k) and mild proprial edema (e) as well as few leukocytic cell infiltration (black arrows), (m,n) Stem (500 mg/kg) group showing regeneration of the mucosal epithelium (black arrows) (m) and minimal leukocytic cell infiltration (red arrows) as well as scant proprial hemorrhage (black arrows) (n), (o,p) Fruit peels (250 mg/kg) treated group showing regeneration of mucosal epithelium (black arrows) (o) and scant proprial hemorrhage(black arrows) (p), and (q,r) Fruit peels (500 mg/kg) treated groups showing normal colonic mucosa (black line) (q) and scant proprial hemorrhage (black arrows) (r). (Stain:H&E; Scale bar = 100 µm).