Table 4 Macroscopic grading of the protective effect of oral administration of MA leaves, pseudostem and fruit peels extracts on colonic ulceration.

From: Pharmacological and metabolomic profiles of Musa acuminata wastes as a new potential source of anti-ulcerative colitis agents

Groups

Ulcer grading

Number

Severity

Ulcer index

% of protection

Negative control

–

–

–

–

Positive control

Acetic acid 8% (2 ml/rat)

5

5

1100

–

Prednisolone (5 mg /kg)

1

0.5

640 ± 4.2@

41.81 ± 0.38

MA leaves (250 mg/kg)

3.25

2.62

933.75 ± 10 76@*

15.11 ± 0.97*

MA leaves (500 mg/kg)

2

1.37

788.57 ± 8.85@*#

28.31 ± 0.8*#

MA pseudostem (250 mg/kg)

2

1.62

786.25 ± 8.64@*#

28.52 ± 0.78*#

MA pseudostem (500 mg/kg)

1.87

1.25

656.25 ± 9.89@#$&

40.34 ± 0.89#$&

MA fruit peels (250 mg/kg)

1.37

0.87

647.5 ± 7.5@#$&

41.13 ± 0.68#$&

MA fruit peels (500 mg/kg)

0.77

0.55

513.33 + 5.59@*#$!€

53.33 ± 0.38*#$&!€

  1. Results are expressed as means of ulcer number, severity, index and % of treatment protective effect ± SE after 14 days of MA extract and prednisolone administration. followed by ulcer induction by single pr acetic acid infusion. n = 8; Data were analysed using one way analysis of variance (ANOVA) followed by Tukey Kramer’s multiple comparison test; Significance was considered at P ≤ 0.05.
  2. @Significantly different from positive control group, *significantly different from prednisolone group, #significantly different from MA leaves 250 mg/kg group, $significantly different from MA leaves 500 mg/kg group, &significantly different from MA pseudostem 250 mg/kg group, !significantly different from MA pseudostem 500 mg/kg group, €significantly different from MA fruit peels 250 mg/kg group.
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