Table 1 In vitro inhibitory activity against SARS-CoV-2 RdRp, kinetic solubility (Sk) in neutral water, microsomal stability (t1/2 micr.) in mouse, and plasma stability (t1/2 pl.) in mouse of luteolin and quercetin.

From: Quercetin and luteolin are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase

Compound

% inhib

100 µM

% inhib

25 µM

IC50

(µM)

Sk

(µM)

t1/2 micr

(min)

t1/2 pl

(min)

Luteolin

100

89

4.6 ± 0.3

21 ± 4

 > 60

 > 120

Quercetin

100

81

6.9 ± 1.0

16 ± 5

 > 60

7 ± 2

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