Table 2 Results of immunohistochemical analysis and treatment outcomes of ICI therapy.
Patient | HLA-DR | CD8 | TIA-1 | T cell infiltration pattern | HLA class I | PD-L1 | FoxP3 | Immunohistogram | Response to ICI | PFS | CSS | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Positive area (%) | Score | Cells/HPF | Score | Cells/HPF | Score | Score | Intensity :positive area (%) | Score | Positive area (%) | Score | Cells/HPF | Score | Months | Months | ||||
RCC01 | 60 | 3 | 288 | 3 | 112 | 3 | Inflamed | 3 | 3:100 | 3 | 60 | 3 | 5 | 1 | Immune-hot | CR | 18.8 | 18.8 |
RCC02 | 50 | 3 | 102 | 3 | 70 | 3 | Inflamed | 3 | 3:80, 1:20 | 3 | 60 | 3 | 5 | 1 | Immune-hot | PR | 36.5 | 36.5 |
RCC03 | 10 | 0 | 50 | 3 | 14 | 2 | Excluded | 1 | 2:60, 1:40 | 2 | 0 | 0 | 0 | 0 | Immune-cold | PR | 23.0 | 52.0 |
RCC04 | 50 | 3 | 88 | 3 | 65 | 3 | Partially inflamed | 2 | 3:50, 1:50 | 3 | 30 | 2 | 0 | 0 | Immune-hot | CR | 30.1 | 30.1 |
RCC05 | 50 | 3 | 324 | 3 | 172 | 3 | Partially inflamed | 2 | 3:100 | 3 | 5 | 1 | 15 | 2 | Immune-hot | SD | 20.0 | 28.6 |
RCC06 | 80 | 3 | 138 | 3 | 160 | 3 | Inflamed | 3 | 3:80, 1:20 | 3 | 10 | 1 | 5 | 1 | Immune-hot | CR | 26.2 | 26.2 |
RCC07 | 0 | 0 | 9 | 1 | 7 | 1 | Excluded | 1 | 3:20, 1:80 | 1 | 100 | 3 | 0 | 0 | Immune-cold | PR | 25.4 | 25.4 |
UTUC01 | 0 | 0 | 8 | 1 | 3 | 1 | Desert | 0 | 2:30, 1:70 | 1 | 0 | 0 | 5 | 0 | Immune-cold | PD | 1.3 | 1.3 |
UTUC02 | 50 | 3 | 114 | 3 | 56 | 3 | Partially inflamed | 2 | 3:70, 2:30 | 3 | 60 | 3 | 10 | 1 | Immune-hot | PR | 17.9 | 17.9 |
UTUC03 | 0 | 0 | 28 | 2 | 13 | 2 | Inflamed | 3 | 3:70, 2:30 | 3 | 0 | 0 | 0 | 0 | Immune-cold | PD | 1.9 | 13.9 |
UTUC04 | 5 | 0 | 16 | 2 | 2 | 1 | Desert | 0 | 3:20, 0:80 | 0 | 5 | 1 | 5 | 1 | Immune-cold | PD | 0.5 | 1.6 |
UTUC05 | 10 | 0 | 29 | 2 | 11 | 2 | Partially inflamed | 2 | 3:80, 2:20 | 3 | 5 | 1 | 5 | 1 | Immune-cold | PD | 0.1 | 1.4 |
BUC01 | 0 | 0 | 81 | 3 | 54 | 3 | Excluded | 1 | 3:100 | 3 | 5 | 1 | 20 | 2 | Immune-cold | PR | 15.4 | 15.4 |
BUC02 | 20 | 1 | 82 | 3 | 31 | 3 | Partially inflamed | 2 | 3:50, 1:50 | 3 | 10 | 1 | 5 | 1 | Immune-hot | SD | 12.7 | 17.1 |
BUC03 | 0 | 0 | 32 | 3 | 13 | 2 | Partially inflamed | 2 | 3:80, 1:20 | 3 | 5 | 1 | 5 | 1 | Immune-cold | SD | 11.2 | 22.2 |
BUC04 | 70 | 3 | 122 | 3 | 63 | 3 | Inflamed | 3 | 3:80, 1:20 | 3 | 60 | 3 | 20 | 2 | Immune-hot | CR | 43.8 | 43.8 |
BUC05 | 0 | 0 | 8 | 1 | 5 | 1 | Desert | 0 | 3:30, 0:70 | 0 | 0 | 0 | 0 | 0 | Immune-cold | PD | 1.3 | 3.3 |
BUC06 | 0 | 0 | 40 | 3 | 18 | 2 | Excluded | 1 | 2:20, 0:80 | 0 | 30 | 2 | 0 | 0 | Immune-cold | PD | 1.2 | 2.8 |
