Figure 3
Re inactivation increased VTEs on choice error sequences. (A) An example rat that exhibited VTEs on every trial following Re inactivation, with > 50% of trials being perseverations. Left panels display position data from an example baseline (gray) and muscimol testing (red) trial. Overlaid are example trajectories where warm colors indicate greater normalized head velocity. Bar graphs (right) demonstrate that this example rat exhibited both perseverative and deliberative choice behaviors during muscimol testing (red) which were less prevalent across the various control conditions (gray) (see Rat 1 Fig. 2A). (B) Percentage of perseveration trials that were VTEs or non-VTEs were used to generate a normalized difference score between control and muscimol sessions. Notice that Re inactivation caused a significant increase to perseveration trials with VTEs but not to perseveration trials with non-VTEs. (C) In general, % perseveration was increased by Re inactivation. (D) Unlike perseveration, which makes no assumption of spatial bias, turn bias reflects a difference between the amount of left and right choices (e.g. |#left–#right|/#trials). Re inactivation did not lead to a reliable increase in turn-bias as measured via one-way repeated measures ANOVA. Notice that the numerical change in turn bias is best explained by the data in (C). Data are displayed as the mean ± s.e.m. **p < 0.01 ***p < 0.001.
