Figure 5 | Scientific Reports

Figure 5

From: The ventral midline thalamus coordinates prefrontal–hippocampal neural synchrony during vicarious trial and error

Figure 5

Re inactivation reduces mPFC-to-dHPC theta directionality during VTEs. (A) Schematic representing LFP extracted from the choice point (left) and a conceptual representation of Granger prediction (right panels). Notice that Granger prediction provides estimates of predictive power in both directions (e.g. PFC-to-HPC and HPC-to-PFC). (B) Re suppression reduced mPFC-to-dHPC theta directionality during VTEs (N = 7) when compared to non-VTEs (N = 6). Note that 5 rats exhibited both VTEs and non-VTEs after reaching inclusion criteria for LFP analyses (see “Results” and “Methods”). (C) Re suppression did not disrupt dHPC theta leading mPFC theta. *p < 0.0167. Data are displayed as the mean ± the s.e.m.

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