Figure 2

Screening for PIP2-associated residues through charge-neutralizing mutations in TRPC6 channels. Current decay (t1/2) and recovery (τ) (n = 5–10) and inhibition ratios (Ipost/Ipre) are shown for each TRPC6 mutation. Asterisks indicate significant differences from TRPC6WT values (*p < 0.05 or **p < 0.01).