Figure 7
The antitumor effect of cinnamon essential oil (Cinn, 50 mg/kg b.wt/day, orally) on Ehrlich ascites carcinoma (EAC) after 12 days of the treatments revealing that Cinn succeded to control tumor cells’ growth by inducing apoptosis and necrosis and cell cycle arrest at G0/G1 phase. The flow cytometric quantification of apoptosis and cell cycle distribution was performed using Annexin V-FITC/PI assay and PI staining, respectively. (A) Flow cytometric dot plot presentations show the percentages of apoptotic and necrotic events, (B) Flow cytometric histograms show the distribution of the cell cycle phases, (C & D). The statistical data of treated and control groups of apoptosis/necrosis and cell cycle phases respectively. All values were presented as mean ± SD, (n = 3). Significant differences (P < 0.05) between groups were shown by different letters. Cis, cisplatin (2 mg/kg b.wt, i.p).
