Table 3 Accuracy of different biomarkers in predicting 30-day mortality.

From: Dynamic changes in heparin-binding protein as a prognostic biomarker for 30-day mortality in sepsis patients in the intensive care unit

Maximize the sum of sensitivity and specificity

Variables

Cut-off

Sensitivity (%)

Specificity (%)

AUC (95% CI)

PCT (ng/dL)

1.79

0.77 (0.65, 0.86)

0.65 (0.57, 0.73)

0.72 (0.65, 0.80)

HBP (ng/mL)

201.69

0.77 (0.65, 0.86)

0.80 (0.72, 0.86)

0.79 (0.72, 0.85)

CRP

110.10

0.53 (0.40, 0.65)

0.78 (0.70, 0.85)

0.65 (0.56, 0.73)

Lactate

3.00

0.59 (0.47, 0.71)

0.75 (0.66, 0.82)

0.71 (0.63, 0.78)

HBPc-24 h (%)

− 23.26

0.63 (0.47, 0.76)

0.60 (0.52, 0.68)

0.60 (0.51, 0.70)

HBPc-48 h (%)

− 17.14

0.58 (0.43, 0.72)

0.91 (0.85, 0.95)

0.82 (0.75, 0.89)

  1. AUC refers to the area under the ROC curves in which the larger AUC means higher discriminative capability. The cutoff was determined to maximize the sum of sensitivity and specificity. PCT, HBP, CRP and Lactate refer to their respective levels at baseline.
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