Figure 4
(A) Distribution of orbital tightening over time contrasted by the within-subjects intervention regimes pre (steel blue)/post (red) in the two treatment groups. The untreated baseline values are shown in week 0 (dark green). Note that in week 1 the animals show higher values after the intervention (red) than in week 0. These differences were not prominent in the control group. Further, the grimace scale thresholds are shown as colored regions on the y-scale (green = mild, orange = moderate, red = severe). In the CCl4 group, more animals were found in the moderate and the severe classes than in the control group. In the CCl4 group, the animals show an elevated baseline (60% of the CCl4 animals in week 0, compared to 38.9% in the Oil group). Further, the fraction of severity was increased in both treatment groups after the intervention. (B) Time-independent cumulative severity estimation. The number of animals in each severity class was counted and expressed as a percentage (fraction). The severity classes are colorized as in (A).
