Figure 2 | Scientific Reports

Figure 2

From: N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma

Figure 2

PLK1 is a poor prognostic factor for pancreatic adenocarcinoma. (a,b) Clinical impact of PLK1 from TCGA data via UALCAN (http://ualcan.path.uab.edu/). (a) PLK1 is elevated in parallel with the pathological grade of pancreatic adenocarcinoma. (b) Patients with pancreatic cancer with elevated PLK1 have poor OS. (c) Histopathological images of PLK1 in patients with pancreatic adenocarcinoma (immunohistochemistry with DAB). PLK1 expression is low in healthy pancreatic tissue, whereas PLK1 is abundantly expressed in pancreatic adenocarcinoma tissue. Pancreatic adenocarcinoma with high METTL3 expression is also presented (same patient with high PLK1). The scale represents 200 µm. (d) High protein expression of PLK1 and METTL3 tends to be associated with poor prognosis in pancreatic adenocarcinoma. A positive correlation between PLK1 and METTL3 was also observed.

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