Figure 4 | Scientific Reports

Figure 4

From: N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma

Figure 4

scRNA-seq and bulk RNA-seq of pancreatic tumors in a WTg mouse model overexpressing METTL3. (a) The data was summarized in the UMAP and color-coded according to sample type (left), and cell type (right). (b) The violin plot shows the comparison of PLK1 expression between WTg and EL1 in the cluster of Beta/Duct/Cancer. (c) GSEA shows the gene sets of cell cycle and mitosis in the cluster of Beta/Duct/Cancer were significantly enriched in WTg compared with EL1. (d) The leading edge analysis shows enriched genes in the cluster of Beta/Duct/Cancer. GO/PPI analysis is shown for genes that appeared in the “HALLMARK” gene sets three or more times. (e) GSEA shows enriched gene sets of nine clones of murine primary cells cultured from tumors of WTg mice compared with six types of mouse embryonic fibroblasts obtained from GSE133753 and GSE193354.

Back to article page