Figure 2 | Scientific Reports

Figure 2

From: The combination of mesoglycan and VEGF promotes skin wound repair by enhancing the activation of endothelial cells and fibroblasts and their cross-talk

Figure 2

Excisional skin wounds on C57BL6 mice were macroscopically photographed at the indicated time (A) the day 0 pictures have been taken immediately after injury, panels a–c; (B) the day 7 of treatments has been represented by panels d–f; (C) the day 10 refers to the sacrifice, panels g–i. Representative results from five individual mice from each group are shown. (D) Wound areas measurements at day 10 calculated as percentage as differences with the diameter of the related lesions at day 0. The data represent a mean of n = 3 independent experiments ± SD based on one-way ANOVA and a two-tailed Student's t-test as appropriated; *p < 0.05, ***p < 0.001 versus PBS treated controls; #p < 0.05; ##p < 0.01 for combination versus mesoglycan or VEGF treated wounds; ¶p < 0.05 for VEGF treatment versus mesoglycan one. (E) Skin sections harvested at day 10 have been stained through H&E (panels a–d). White arrows indicate new blood vessels. Magnification ×10. Bar = 100 µm.

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