Figure 5

Mesoglycan and VEGF, both of them, directly trigger the activation of fibroblasts and endothelial cells. Thus, in wound repair, granulation and angiogenesis processes are induced. Moreover, endothelial cells, once engaged in the formation of the new vessels, further promote the deposition of granulation tissue by fibroblasts. In this way, a positive feed-back is induced by the combination of mesoglycan and VEGF favoring the cross-talk between two of the crucial cell populations involved in tissue regeneration.